Topical 3-bromopyruvate is a novel targeted therapy for melanoma in a preclinical model
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چکیده
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assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
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15 صفحه اولA Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors
Mutant serine/threonine protein kinase B-Raf (BRAF) protein is expressed in over half of all melanoma tumors. Although BRAF inhibitors (BRAFi) elicit rapid anti-tumor responses in the majority of patients with mutant BRAF melanoma, the tumors inevitably relapse after a short time. We hypothesized that polyamines are essential for tumor survival in mutant BRAF melanomas. These tumors rely on bot...
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Purpose: This study characterized the therapeutic efficacy of a systemically administered formulation of 3-bromopyruvate (3-BrPA), microencapsulated in a complex with b-cyclodextrin (b-CD), using an orthotopic xenograft mouse model of pancreatic ductal adenocarcinoma (PDAC). ExperimentalDesign: The presence of the b-CD–3-BrPA complexwas confirmedusing nuclearmagnetic resonance spectroscopy. Mon...
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In this research, in order to improve our calculations in treatment planning for proton radiotherapy of ocular melanoma, we improved our human eye phantom planning system in GEANT4 toolkit. Different analytical models have investigated the creating of Spread Out Bragg Peak (SOBP) in the tumor area. Bortfeld’s model is one of the most important analytical methods. Using convolution method, a new...
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The incidence of malignant melanoma is increasing worldwide, despite our best efforts in prevention and early detection. The locally advanced disease may be treated surgically with good results, however, metastatic melanoma is considered to be one of the most therapeutically challenging malignancies. The increasing knowledge of molecular changes in melanoma may change this picture. Malignant me...
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ژورنال
عنوان ژورنال: Journal of Dermatological Science
سال: 2018
ISSN: 0923-1811
DOI: 10.1016/j.jdermsci.2018.08.009